FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
RAD51
反应性
Human,Mouse,Rat,Monkey
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
37kD
推荐稀释比
WB 1:1000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Recombinant protein of human Rad51.
特异性
This antibody detects endogenous levels of Rad51 and does not cross-react with related proteins.
基因名称
rad51
别名
BRCA1/BRCA2 containing complex, subunit 5;BRCC 5;BRCC5;DNA repair protein RAD51 homolog 1;DNA repair protein rhp51;HRAD51;HsRad51;HsT16930;MRMV2;Rad 51;RAD51;RAD51 homolog;RecA homolog, E. coli;S. cerevisiae;RAD51 homolog A;RAD51 homolog;RAD51 recombinase;RAD51, S. cerevisiae, homolog of;RAD51_HUMAN;RAD51A;RECA;RecA like protein;RecA, E. coli, homolog of;Recombination protein A.
Organism-1
Human
基因ID-1
5888
SwissProt-1
Q06609
Organism-2
Mouse
SwissProt-2
Q08297
背景
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009],
细胞定位
Nucleus . Cytoplasm . Cytoplasm, perinuclear region. Mitochondrion matrix . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage (PubMed:20154705). DNA damage induces an increase in nuclear levels (PubMed:20154705). Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment (PubMed:23754376). Accumulated at sites of DNA damage in a SPIDR-dependent manner (PubMed:23509288). Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner (PubMed:23401855). Colocalizes with ERCC5/XPG to nuclear foci in S phase (PubMed:26833090). .
