FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
GSK3β
反应性
Human,Mouse
应用
WB,IF,IP
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
46kD
推荐稀释比
WB 1:1000;ICC 1:200;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant GSK-3β protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of GSK-3β and does not cross-react with related proteins.
基因名称
gsk-3 beta
别名
Glycogen Synthase Kinase 3 Beta;Glycogen synthase kinase-3 beta;GSK 3 beta;GSK-3 beta;GSK3B;GSK3B_HUMAN;GSK3beta isoform;Serine/threonine-protein kinase GSK3B.
Organism-1
Human
基因ID-1
2932
SwissProt-1
P49841
Organism-2
Mouse
SwissProt-2
Q9WV60
背景
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],
细胞定位
Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .
