FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MEK1
反应性
Human
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
45kD
推荐稀释比
WB 1:500
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Recombinant human MEK1 protein.
特异性
This antibody detects endogenous levels of MEK1/2 and does not cross-react with related proteins.
基因名称
MEK1/2
别名
AA589381;Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2;ERK activator kinase 1;ERK activator kinase 2;FLJ26075;MAP kinase kinase 1;MAP kinase kinase 2;MAP2K1;MAP2K2;MAPK/ERK kinase 1;MAPK/ERK kinase 2;MAPKK 1;MAPKK1;MAPKK2;MEK 1;MEKK1;Mitogen activated protein kinase kinase 1;Mitogen activated protein kinase kinase 2;Mitogen-activated protein kinase kinase 2, p45;MK2;MKK 1;MKK 2;MKK1;MKK2;MP2K1_HUMAN;PRKMK 1;PRKMK 2;Prkmk1;Prkmk2;protein kinase, mitogen-activated, kinase 1;MAP kinase kinase 1;Protein kinase, mitogen-activated, kinase 1;Protein kinase, mitogen-activated, kinase 2.
Organism-1
Human
基因ID-1
56045605
SwissProt-1
P36507;Q02750
背景
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008],
细胞定位
extracellular region,nucleus,cytoplasm,mitochondrion,early endosome,late endosome,peroxisomal membrane,endoplasmic reticulum,Golgi apparatus,cytosol,microtubule,cell-cell junction,focal adhesio
