FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
UHRF1
反应性
Human,Mouse
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Observed)
90kD
推荐稀释比
WB 1:1000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human UHRF1 protein fragments expressed in E.coil.
特异性
This antibody detects endogenous levels of UHRF1 and does not cross-react with related proteins
基因名称
uhrf1
别名
Ac2-121;AL022808;E3 ubiquitin-protein ligase UHRF1;FLJ21925;Hnp95 Huhrf1;HuNp95;ICBP90;Inverted CCAAT box binding protein of 90 kDa;Inverted CCAAT box binding protein, 90-Kd;Inverted CCAAT box-binding protein of 90 kDa;Liver regeneration-related protein LRRG126;MGC138707;NP95;Nuclear phosphoprotein, 95-KD;Nuclear protein 95;Nuclear zinc finger protein Np95;RING finger protein 106;RNF106;Transcription factor ICBP90;Ubiquitin like containing PHD and RING finger domains protein 1;Ubiquitin like PHD and RING finger domain containing protein 1;Ubiquitin-like PHD and RING finger domain-containing protein 1;Ubiquitin-like protein containing PHD and RING finger domains 1;Ubiquitin-like with PHD and ring finger domains 1;Ubiquitin-like, containing PHD and RING finger domains, 1;Ubiquitin-like-containing PHD and RING finger domains protein 1;UHRF1;UHRF1_HUMAN.
Organism-1
Human
基因ID-1
29128
SwissProt-1
Q96T88
Organism-2
Mouse
SwissProt-2
Q8VDF2
背景
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014],
细胞定位
Nucleus . Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions.
