FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
WDR79
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
59kD
推荐稀释比
WB 1:1000-1:2000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human WDR79 protein fragments expressed in E.coli.
特异性
WDR79 Monoclonal Antibody detects endogenous levels of WDR79 protein.
基因名称
WRAP53
蛋白名称
Telomerase Cajal body protein 1
别名
WRAP53;TCAB1;WDR79;Telomerase Cajal body protein 1;WD repeat-containing protein 79;WD40 repeat-containing protein encoding RNA antisense to p53
Organism-1
Human
基因ID-1
55135
SwissProt-1
Q9BUR4
Organism-2
Mouse
基因ID-2
216853
SwissProt-2
Q8VC51
Organism-3
Rat
基因ID-3
287432
SwissProt-3
Q5XII5
背景
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011],
细胞定位
Nucleus, Cajal body . Chromosome, telomere . Chromosome . Released from telomerase RNA template component (TERC) in mitotic cells coincident with delocalization from Cajal bodies (PubMed:26170453). In response to DNA damage, localizes to sites of DNA double-strand breaks following phosphorylation by ATM (PubMed:26734725, PubMed:27715493). .
