FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
uMtCK
反应性
Human,Mouse,Rat,Dog,Pig,Rabbit
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
47kD
推荐稀释比
WB 1:1000-1:2000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human uMtCK protein fragments expressed in E.coli.
特异性
uMtCK Monoclonal Antibody detects endogenous levels of uMtCK protein.
基因名称
CKMT1A/CKMT1B
蛋白名称
Creatine kinase U-type mitochondrial
别名
CKMT1A;CKMT;CKMT1B;CKMT;Creatine kinase U-type;mitochondrial;Acidic-type mitochondrial creatine kinase;Mia-CK;Ubiquitous mitochondrial creatine kinase;U-MtCK
Organism-1
Human
基因ID-1
1159;548596
SwissProt-1
P12532
Organism-2
Mouse
基因ID-2
12716
SwissProt-2
P30275
Organism-3
Rat
SwissProt-3
P25809
背景
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mi
细胞定位
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
