FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PRMT1
反应性
Human,Mouse,Rat,Dog,Rabbit
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
42kD
推荐稀释比
WB 1:1000-1:2000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human PRMT1 protein fragments expressed in E.coli.
特异性
PRMT1 Monoclonal Antibody detects endogenous levels of PRMT1 protein.
基因名称
PRMT1
蛋白名称
Protein arginine N-methyltransferase 1
别名
PRMT1;HMT2;HRMT1L2;IR1B4;Protein arginine N-methyltransferase 1;Histone-arginine N-methyltransferase PRMT1;Interferon receptor 1-bound protein 4
Organism-1
Human
基因ID-1
3276
SwissProt-1
Q99873
Organism-2
Mouse
基因ID-2
15469
SwissProt-2
Q9JIF0
Organism-3
Rat
基因ID-3
60421
SwissProt-3
Q63009
背景
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011],
细胞定位
Nucleus . Nucleus, nucleoplasm . Cytoplasm . Cytoplasm, cytosol . Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). .
