FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PP2B-Aα
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
59kD
推荐稀释比
WB 1:1000-1:2000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human PP2B-Aα protein fragments expressed in E.coli.
特异性
PP2B-Aα Monoclonal Antibody detects endogenous levels of PP2B-Aα protein.
基因名称
PPP3CA
蛋白名称
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
别名
PPP3CA;CALNA;CNA;Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform;CAM-PRP catalytic subunit;Calmodulin-dependent calcineurin A subunit alpha isoform
Organism-1
Human
基因ID-1
5530
SwissProt-1
Q08209
Organism-2
Mouse
基因ID-2
19055
SwissProt-2
P63328
Organism-3
Rat
基因ID-3
24674
SwissProt-3
P63329
背景
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 Fe(3+) ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.,online information:Calcineurin entry,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-2B subfamily.,subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.,subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.,
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein . Cell membrane, sarcolemma . Cytoplasm, myofibril, sarcomere, Z line . Cell projection, dendritic spine . Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca(2+)-channel activation (PubMed:22343722). .
