FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PP1α
反应性
Human,Mouse,Rat,Bovine,Chicken,Pig,Rabbit,Zebrafish
应用
WB,IF
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
38kD
推荐稀释比
WB 1:1000-1:2000;IF 1:100-1:500;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human PP1α (N-terminus) protein fragments expressed in E.coli.
特异性
PP1α Monoclonal Antibody detects endogenous levels of PP1α protein.
基因名称
PPP1CA
蛋白名称
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
别名
PPP1CA;PPP1A;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;PP-1A
Organism-1
Human
基因ID-1
5499
SwissProt-1
P62136
Organism-2
Mouse
基因ID-2
19045
SwissProt-2
P62137
Organism-3
Rat
基因ID-3
24668
SwissProt-3
P62138
背景
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Nucleus . Nucleus, nucleoplasm . Nucleus, nucleolus . Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. Shuttles toward the cytosol during infection with VEEV (PubMed:29769351). .
