FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Nup98
反应性
Human,Mouse,Dog
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
198kD
推荐稀释比
WB 1:1000-1:2000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human Nup98 protein fragments expressed in E.coli.
特异性
Nup98 Monoclonal Antibody detects endogenous levels of Nup98 protein.
基因名称
NUP98
蛋白名称
Nuclear pore complex protein Nup98-Nup96
别名
NUP98;ADAR2;Nuclear pore complex protein Nup98-Nup96
Organism-1
Human
基因ID-1
4928
SwissProt-1
P52948
背景
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of
细胞定位
Nucleus membrane ; Peripheral membrane protein; Nucleoplasmic side . Nucleus, nuclear pore complex . Nucleus, nucleoplasm . Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the dissasembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (PubMed:11839768, PubMed:28221134). .; Nucleus membrane . (Microbial infection) Remains localized to the nuclear membrane after poliovirus (PV) infection. .
