FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
NSD1
反应性
Human
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
297kD
推荐稀释比
WB 1:1000-1:2000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human NSD1 protein fragments expressed in E.coli.
特异性
NSD1 Monoclonal Antibody detects endogenous levels of NSD1 protein.
基因名称
NSD1
蛋白名称
Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific
别名
NSD1;ARA267;KMT3B;Histone-lysine N-methyltransferase;H3 lysine-36 and H4 lysine-20 specific;Androgen receptor coactivator 267 kDa protein;Androgen receptor-associated protein of 267 kDa;H3-K36-HMTase;H4-K20-HMTase;Lysine N-methyltr
Organism-1
Human
基因ID-1
64324
SwissProt-1
Q96L73
Organism-2
Mouse
SwissProt-2
O88491
背景
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isofo
细胞定位
Nucleus. Chromosome .
