FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
HXK II
反应性
Human,Mouse,Rat,Pig
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
102kD
推荐稀释比
WB 1:1000-1:2000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human HXK II (N-terminus) protein fragments expressed in E.coli.
特异性
HXK II Monoclonal Antibody detects endogenous levels of HXK II protein.
基因名称
HK2
蛋白名称
Hexokinase-2
别名
HK2;Hexokinase-2;Hexokinase type II;HK II;Muscle form hexokinase
Organism-1
Human
基因ID-1
3099
SwissProt-1
P52789
Organism-2
Mouse
基因ID-2
15277
SwissProt-2
O08528
Organism-3
Rat
基因ID-3
25059
SwissProt-3
P27881
背景
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009],
细胞定位
Mitochondrion outer membrane ; Peripheral membrane protein . Cytoplasm, cytosol . The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880). Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175). .
