FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
HP1α
反应性
Human,Mouse,Rat,Bovine,Dog,Pig
应用
WB,IF
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
22kD
推荐稀释比
WB 1:1000-1:2000;IF 1:100-1:500;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human HP1α protein fragments expressed in E.coli.
特异性
HP1α Monoclonal Antibody detects endogenous levels of HP1α protein.
基因名称
CBX5
蛋白名称
Chromobox protein homolog 5
别名
CBX5;HP1A;Chromobox protein homolog 5;Antigen p25;Heterochromatin protein 1 homolog alpha;HP1 alpha
Organism-1
Human
基因ID-1
23468
SwissProt-1
P45973
Organism-2
Mouse
基因ID-2
12419
SwissProt-2
Q61686
背景
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Chromosome . Chromosome, centromere . Colocalizes with HNRNPU in the nucleus (PubMed:19617346). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. .
