FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
hnRNP U
反应性
Human,Bovine,Pig,Rabbit
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
91kD
推荐稀释比
WB 1:1000-1:2000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human hnRNP U protein fragments expressed in E.coli.
特异性
hnRNP U Monoclonal Antibody detects endogenous levels of hnRNP U protein.
基因名称
HNRNPU
蛋白名称
Heterogeneous nuclear ribonucleoprotein U
别名
HNRNPU;HNRPU;SAFA;U21.1;Heterogeneous nuclear ribonucleoprotein U;hnRNP U;Scaffold attachment factor A;SAF-A;p120;pp120
Organism-1
Human
基因ID-1
3192
SwissProt-1
Q00839
Organism-2
Mouse
SwissProt-2
Q8VEK3
背景
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the
细胞定位
Nucleus . Nucleus matrix . Chromosome . Nucleus speckle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Midbody . Cytoplasm . Cell surface . Cytoplasmic granule . Localizes at inactive X chromosome (Xi) regions (PubMed:11003645, PubMed:14608463, PubMed:15563465). Localizes in the nucleus during interphase (PubMed:21242313). At metaphase, localizes with mitotic spindle microtubules (MTs) (PubMed:21242313). At anaphase, localizes in the mitotic spindle midzone (PubMed:21242313). Localizes in spindle MTs proximal to spindle poles in a TPX2- and AURKA-dependent manner (PubMed:21242313). The Ser-59 phosphorylated form localizes to centrosomes during prophase and metaphase, to mitotic spindles in anaphase and to the midbody during cytokinesis (PubMed:25986610). Colocalizes with SMARCA4 in the nucleus (By similarity). Colocalizes with CBX5 in the nucleus (PubMed:19617346). Colocalizes with NR3C1 in nuclear speckles (PubMed:9353307). Localized in cytoplasmic ribonucleoprotein (RNP) granules containing untranslated mRNAs (PubMed:17289661). .
