FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
HDAC4
反应性
Human,Mouse,Rat
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
119kD
推荐稀释比
WB 1:1000-1:2000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human HDAC4 (N-terminus) protein fragments expressed in E.coli.
特异性
HDAC4 Monoclonal Antibody detects endogenous levels of HDAC4 protein.
基因名称
HDAC4
蛋白名称
Histone deacetylase 4
别名
HDAC4;KIAA0288;Histone deacetylase 4;HD4
Organism-1
Human
基因ID-1
9759
SwissProt-1
P56524
Organism-2
Mouse
基因ID-2
208727
SwissProt-2
Q6NZM9
Organism-3
Rat
基因ID-3
363287
SwissProt-3
Q99P99
背景
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity). .
