FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
HAUSP
反应性
Human,Mouse,Rat,Dog,Pig
应用
WB,IF
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
128kD
推荐稀释比
WB 1:1000-1:2000;IF 1:100-1:500;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human HAUSP (C-terminus) protein fragments expressed in E.coli.
特异性
HAUSP Monoclonal Antibody detects endogenous levels of HAUSP protein.
基因名称
USP7
蛋白名称
Ubiquitin carboxyl-terminal hydrolase 7
别名
USP7;HAUSP;Ubiquitin carboxyl-terminal hydrolase 7;Deubiquitinating enzyme 7;Herpesvirus-associated ubiquitin-specific protease;Ubiquitin thioesterase 7;Ubiquitin-specific-processing protease 7
Organism-1
Human
基因ID-1
7874
SwissProt-1
Q93009
Organism-2
Mouse
基因ID-2
252870
SwissProt-2
Q6A4J8
Organism-3
Rat
基因ID-3
360471
SwissProt-3
Q4VSI4
背景
The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016],
细胞定位
Nucleus . Cytoplasm . Nucleus, PML body . Chromosome . Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.
