FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CYP7A1
反应性
Human,Golden hamster
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
58kD
推荐稀释比
WB 1:1000-1:2000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human CYP7A1 (C-terminus) protein fragments expressed in E.coli.
特异性
CYP7A1 Monoclonal Antibody detects endogenous levels of CYP7A1 protein.
基因名称
CYP7A1
蛋白名称
Cholesterol 7-alpha-monooxygenase
别名
CYP7A1;CYP7;Cholesterol 7-alpha-monooxygenase;CYPVII;Cholesterol 7-alpha-hydroxylase;Cytochrome P450 7A1
Organism-1
Human
基因ID-1
1581
SwissProt-1
P22680
Organism-2
Mouse
SwissProt-2
Q64505
背景
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010],
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein . Microsome membrane ; Single-pass membrane protein .
