FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Crk II
反应性
Human,Mouse,Dog,Rabbit
应用
WB
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
34kD
推荐稀释比
WB 1:1000-1:2000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human Crk II protein fragments expressed in E.coli.
特异性
Crk II Monoclonal Antibody detects endogenous levels of Crk II protein.
基因名称
CRK
蛋白名称
Adapter molecule crk
别名
CRK;Adapter molecule crk;Proto-oncogene c-Crk;p38
Organism-1
Human
基因ID-1
1398
SwissProt-1
P46108
Organism-2
Mouse
基因ID-2
12928
SwissProt-2
Q64010
Organism-3
Rat
SwissProt-3
Q63768
背景
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Cell membrane . Translocated to the plasma membrane upon cell adhesion. .
