FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Arrestin-β-2
反应性
Human,Mouse,Rat,Pig
应用
WB,IF
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
46kD
推荐稀释比
WB 1:1000-1:2000;IF 1:100-1:500;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human Arrestin-β-2 (C-terminus) protein fragments expressed in E.coli.
特异性
Arrestin-β-2 Monoclonal Antibody detects endogenous levels of Arrestin-β-2 protein.
基因名称
ARRB2
蛋白名称
Beta-arrestin-2
别名
ARRB2;ARB2;ARR2;Beta-arrestin-2;Arrestin beta-2
Organism-1
Human
基因ID-1
409
SwissProt-1
P32121
Organism-2
Mouse
基因ID-2
216869
SwissProt-2
Q91YI4
Organism-3
Rat
基因ID-3
25388
SwissProt-3
P29067
背景
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012],
细胞定位
Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.
