FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Actinin-α2
反应性
Human,Rat,Bovine,Chicken,Dog,Pig,Zebrafish
应用
WB,IF
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
104kD
推荐稀释比
WB 1:1000-1:2000;IF 1:100-1:500;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant human Actinin-α2 (C-terminus) protein fragments expressed in E.coli.
特异性
Actinin-α2 Monoclonal Antibody detects endogenous levels of Actinin-α2 protein.
基因名称
ACTN2/ACTN3
蛋白名称
Alpha-actinin-2
别名
ACTN2;Alpha-actinin-2;Alpha-actinin skeletal muscle isoform 2;F-actin cross-linking protein
Organism-1
Human
基因ID-1
88
SwissProt-1
P35609
Organism-2
Mouse
SwissProt-2
Q9JI91
背景
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013],
细胞定位
Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
