FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Wnt-1
反应性
Human,Mouse
应用
WB,IHC,IF,Flow Cyt,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
41kD
推荐稀释比
WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of Wnt-1 expressed in E. Coli.
特异性
Wnt-1 Monoclonal Antibody detects endogenous levels of Wnt-1 protein.
基因名称
WNT1
蛋白名称
Proto-oncogene Wnt-1
别名
WNT1;INT1;Proto-oncogene Wnt-1;Proto-oncogene Int-1 homolog
Organism-1
Human
基因ID-1
7471
SwissProt-1
P04628
Organism-2
Mouse
基因ID-2
22408
SwissProt-2
P04426
背景
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in
细胞定位
Secreted, extracellular space, extracellular matrix . Secreted .
