FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
TORC2
反应性
Human,Monkey
应用
WB,IHC,IF,Flow Cyt,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
73kD
推荐稀释比
WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human TORC2 expressed in E. Coli.
特异性
TORC2 Monoclonal Antibody detects endogenous levels of TORC2 protein.
基因名称
CRTC2
蛋白名称
CREB-regulated transcription coactivator 2
别名
CRTC2;TORC2;CREB-regulated transcription coactivator 2;Transducer of regulated cAMP response element-binding protein 2;TORC-2;Transducer of CREB protein 2
Organism-1
Human
基因ID-1
200186
SwissProt-1
Q53ET0
Organism-2
Mouse
SwissProt-2
Q3U182
背景
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010],
细胞定位
Cytoplasm . Nucleus . Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein (PubMed:15454081). In response to cAMP levels and glucagon, relocated to the nucleus (PubMed:15454081). .
