FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
TAB2
反应性
Human
应用
WB,Flow Cyt,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
76kD
推荐稀释比
WB 1:500-1:2000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human TAB2 expressed in E. Coli.
特异性
TAB2 Monoclonal Antibody detects endogenous levels of TAB2 protein.
基因名称
TAB2
蛋白名称
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
别名
TAB2;KIAA0733;MAP3K7IP2;TGF-beta-activated kinase 1 and MAP3K7-binding protein 2;Mitogen-activated protein kinase kinase kinase 7-interacting protein 2;TAK1-binding protein 2;TAB-2;TGF-beta-activated kinase 1-binding protein 2
Organism-1
Human
基因ID-1
23118
SwissProt-1
Q9NYJ8
Organism-2
Mouse
SwissProt-2
Q99K90
背景
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
细胞定位
Membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Following IL1 stimulation, translocation occurs from the membrane to cytosol (PubMed:10882101). Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome (PubMed:24434549). .
