FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Stat6
反应性
Human,Mouse,Rat,Monkey
应用
WB,IF,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
94kD
推荐稀释比
WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human Stat6 expressed in E. Coli.
特异性
Stat6 Monoclonal Antibody detects endogenous levels of Stat6 protein.
基因名称
STAT6
蛋白名称
Signal transducer and activator of transcription 6
别名
STAT6;Signal transducer and activator of transcription 6;IL-4 Stat
Organism-1
Human
基因ID-1
6778
SwissProt-1
P42226
Organism-2
Mouse
基因ID-2
20852
SwissProt-2
P52633
背景
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
细胞定位
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
