FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Rb
反应性
Human
应用
IHC,IF,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
推荐稀释比
IHC 1:200-1:1000;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human Rb expressed in E. Coli.
特异性
Rb Monoclonal Antibody detects endogenous levels of Rb protein.
基因名称
RB1
蛋白名称
Retinoblastoma-associated protein
别名
RB1;Retinoblastoma-associated protein;p105-Rb;pRb;Rb;pp110
Organism-1
Human
基因ID-1
5925
SwissProt-1
P06400
Organism-2
Mouse
SwissProt-2
P13405
背景
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. .
