FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PR3
反应性
Human
应用
WB,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
28kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human PR3 expressed in E. Coli.
特异性
PR3 Monoclonal Antibody detects endogenous levels of PR3 protein.
基因名称
PRTN3
蛋白名称
Myeloblastin
别名
PRTN3;MBN;Myeloblastin;AGP7;C-ANCA antigen;Leukocyte proteinase 3;PR-3;PR3;Neutrophil proteinase 4;NP-4;P29;Wegener autoantigen
Organism-1
Human
基因ID-1
5657
SwissProt-1
P24158
Organism-2
Mouse
SwissProt-2
Q61096
背景
catalytic activity:Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-.,function:Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.,online information:Proteinase 3 entry,similarity:Belongs to the peptidase S1 family. Elastase subfamily.,similarity:Contains 1 peptidase S1 domain.,
细胞定位
Cytoplasmic granule . Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Membrane raft ; Peripheral membrane protein ; Extracellular side . Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils (PubMed:2033050, PubMed:3198760, PubMed:7897245, PubMed:18462208). Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (PubMed:22266279, PubMed:28240246). Following secretion tethered to the cell membrane by CD177 (PubMed:18462208, PubMed:22266279). .
