FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PGC-1α
反应性
Human
应用
WB,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
91kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human PGC-1α expressed in E. Coli.
特异性
PGC-1α Monoclonal Antibody detects endogenous levels of PGC-1α protein.
基因名称
PPARGC1A
蛋白名称
Peroxisome proliferator-activated receptor gamma coactivator 1-alp
别名
PPARGC1A;LEM6;PGC1;PGC1A;PPARGC1;Peroxisome proliferator-activated receptor gamma coactivator 1-alpha;PGC-1-alpha;PPAR-gamma coactivator 1-alpha;PPARGC-1-alpha;Ligand effect modulator 6
Organism-1
Human
基因ID-1
10891
SwissProt-1
Q9UBK2
Organism-2
Mouse
SwissProt-2
O70343
背景
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008],
细胞定位
[Isoform 1]: Nucleus . Nucleus, PML body .; [Isoform B4]: Nucleus .; [Isoform B4-8a]: Cytoplasm . Nucleus .; [Isoform B5]: Nucleus . Nucleus, PML body .; [Isoform 9]: Nucleus .
