FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
PERK
反应性
Human
应用
WB,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
125kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human PERK expressed in E. Coli.
特异性
PERK Monoclonal Antibody detects endogenous levels of PERK protein.
基因名称
EIF2AK3
蛋白名称
Eukaryotic translation initiation factor 2-alpha kinase 3
别名
EIF2AK3;PEK;PERK;Eukaryotic translation initiation factor 2-alpha kinase 3;PRKR-like endoplasmic reticulum kinase;Pancreatic eIF2-alpha kinase;HsPEK
Organism-1
Human
基因ID-1
9451
SwissProt-1
Q9NZJ5
Organism-2
Mouse
SwissProt-2
Q9Z2B5
背景
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],
细胞定位
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
