FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MDMX
反应性
Human
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
55kD
推荐稀释比
WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human MDMX expressed in E. Coli.
特异性
MDMX Monoclonal Antibody detects endogenous levels of MDMX protein.
基因名称
MDM4
蛋白名称
Protein Mdm4
别名
MDM4;MDMX;Protein Mdm4;Double minute 4 protein;Mdm2-like p53-binding protein;Protein Mdmx;p53-binding protein Mdm4
Organism-1
Human
基因ID-1
4194
SwissProt-1
O15151
Organism-2
Mouse
SwissProt-2
O35618
背景
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011],
细胞定位
Nucleus.
