FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
LKB1
反应性
Human,Mouse,Monkey
应用
WB,Flow Cyt,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
49kD
推荐稀释比
WB 1:500-1:2000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human LKB1 expressed in E. Coli.
特异性
LKB1 Monoclonal Antibody detects endogenous levels of LKB1 protein.
基因名称
STK11
蛋白名称
Serine/threonine-protein kinase 11
别名
STK11;LKB1;PJS;Serine/threonine-protein kinase STK11;Liver kinase B1;LKB1;hLKB1;Renal carcinoma antigen NY-REN-19
Organism-1
Human
基因ID-1
6794
SwissProt-1
Q15831
Organism-2
Mouse
基因ID-2
20869
SwissProt-2
Q9WTK7
背景
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus. Cytoplasm. Membrane . Mitochondrion. A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. PTEN promotes cytoplasmic localization. .; [Isoform 2]: Nucleus . Cytoplasm . Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.
