FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
KLHL12
反应性
Human
应用
WB,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
63kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human KLHL12 expressed in E. Coli.
特异性
KLHL12 Monoclonal Antibody detects endogenous levels of KLHL12 protein.
基因名称
KLHL12
蛋白名称
Kelch-like protein 12
别名
KLHL12;C3IP1;Kelch-like protein 12;CUL3-interacting protein 1;DKIR homolog;hDKIR
Organism-1
Human
基因ID-1
59349
SwissProt-1
Q53G59
Organism-2
Mouse
SwissProt-2
Q8BZM0
背景
This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
细胞定位
Cytoplasmic vesicle, COPII-coated vesicle .
