FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
JNK3
反应性
Human,Mouse
应用
WB,IF,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
53kD
推荐稀释比
WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human JNK3 (aa28-233) expressed in E. Coli.
特异性
JNK3 Monoclonal Antibody detects endogenous levels of JNK3 protein.
基因名称
MAPK10
蛋白名称
Mitogen-activated protein kinase 10
别名
MAPK10;JNK3;JNK3A;PRKM10;SAPK1B;Mitogen-activated protein kinase 10;MAP kinase 10;MAPK 10;MAP kinase p49 3F12;Stress-activated protein kinase 1b;SAPK1b;Stress-activated protein kinase JNK3;c-Jun N-terminal kinase 3
Organism-1
Human
基因ID-1
5602
SwissProt-1
P53779
Organism-2
Mouse
SwissProt-2
Q61831
背景
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015],
细胞定位
Cytoplasm . Membrane ; Lipid-anchor . Nucleus . Mitochondrion . Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). .
