FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
GSK3β
反应性
Human,Mouse,Rat,Monkey
应用
WB,IHC,IF,Flow Cyt,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
47kD
推荐稀释比
WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human GSK3β expressed in E. Coli.
特异性
GSK3β Monoclonal Antibody detects endogenous levels of GSK3β protein.
基因名称
GSK3B
蛋白名称
Glycogen synthase kinase-3 beta
别名
GSK3B;Glycogen synthase kinase-3 beta;GSK-3 beta;Serine/threonine-protein kinase GSK3B
Organism-1
Human
基因ID-1
2942
SwissProt-1
P49841
Organism-2
Mouse
基因ID-2
56637
SwissProt-2
Q9WV60
Organism-3
Rat
基因ID-3
84027
SwissProt-3
P18266
背景
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],
细胞定位
Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .
