FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Gfi-1
反应性
Human
应用
WB,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
45kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human Gfi-1 expressed in E. Coli.
特异性
Gfi-1 Monoclonal Antibody detects endogenous levels of Gfi-1 protein.
基因名称
GFI1
蛋白名称
Zinc finger protein Gfi-1
别名
GFI1;ZNF163;Zinc finger protein Gfi-1;Growth factor independent protein 1;Zinc finger protein 163
Organism-1
Human
基因ID-1
2672
SwissProt-1
Q99684
Organism-2
Mouse
SwissProt-2
P70338
背景
This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Colocalizes with PIAS3 and RUNX1T1 in nuclear dots.
