FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Fibulin-5
反应性
Human
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
50kD
推荐稀释比
WB 1:500-1:2000;IHC 1:200-1:1000;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of Fibulin-5 expressed in E. Coli.
特异性
Fibulin-5 Monoclonal Antibody detects endogenous levels of Fibulin-5 protein.
基因名称
FBLN5
蛋白名称
Fibulin-5
别名
FBLN5;DANCE;Fibulin-5;FIBL-5;Developmental arteries and neural crest EGF-like protein;Dance;Urine p50 protein;UP50
Organism-1
Human
基因ID-1
10516
SwissProt-1
Q9UBX5
Organism-2
Mouse
SwissProt-2
Q9WVH9
背景
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008],
细胞定位
Secreted . Secreted, extracellular space, extracellular matrix . co-localizes with ELN in elastic fibers. .
