FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
FGFR-4
反应性
Human
应用
WB,IF,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
88kD
推荐稀释比
WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant extracellular fragment of human FGFR-4 fused with hIgGFc tag expressed in HEK293 cell line.
特异性
FGFR-4 Monoclonal Antibody detects endogenous levels of FGFR-4 protein.
基因名称
FGFR4
蛋白名称
Fibroblast growth factor receptor 4
别名
FGFR4;JTK2;TKF;Fibroblast growth factor receptor 4;FGFR-4;CD antigen CD334
Organism-1
Human
基因ID-1
2264
SwissProt-1
P22455
Organism-2
Mouse
SwissProt-2
Q03142
背景
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgII
细胞定位
Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.; [Isoform 2]: Secreted.; [Isoform 3]: Cytoplasm .
