FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Factor VIII
反应性
Human
应用
WB,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
267kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of Factor VIII expressed in E. Coli.
特异性
Factor VIII Monoclonal Antibody detects endogenous levels of Factor VIII protein.
基因名称
F8
蛋白名称
Coagulation factor VIII
别名
F8;F8C;Coagulation factor VIII;Antihemophilic factor;AHF;Procoagulant component
Organism-1
Human
基因ID-1
2157
SwissProt-1
P00451
Organism-2
Mouse
SwissProt-2
Q06194
背景
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008],
细胞定位
Secreted, extracellular space.
