FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Csk
反应性
Human,Mouse,Rat,Monkey
应用
WB,IF,Flow Cyt,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
51kD
推荐稀释比
WB 1:500-1:2000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human Csk expressed in E. Coli.
特异性
Csk Monoclonal Antibody detects endogenous levels of Csk protein.
基因名称
CSK
蛋白名称
Tyrosine-protein kinase CSK
别名
CSK;Tyrosine-protein kinase CSK;C-Src kinase;Protein-tyrosine kinase CYL
Organism-1
Human
基因ID-1
1445
SwissProt-1
P41240
Organism-2
Mouse
基因ID-2
12988
SwissProt-2
P41241
Organism-3
Rat
基因ID-3
315707
SwissProt-3
P32577
背景
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,
细胞定位
Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .
