FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Chk1
反应性
Human,Mouse
应用
WB,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
54kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of Chk1 expressed in E. Coli.
特异性
Chk1 Monoclonal Antibody detects endogenous levels of Chk1 protein.
基因名称
CHK1
蛋白名称
Serine/threonine-protein kinase Chk1
别名
CHEK1;CHK1;Serine/threonine-protein kinase Chk1;CHK1 checkpoint homolog;Cell cycle checkpoint kinase;Checkpoint kinase-1
Organism-1
Human
基因ID-1
1111
SwissProt-1
O14757
Organism-2
Mouse
基因ID-2
12649
SwissProt-2
O35280
背景
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011],
细胞定位
Nucleus . Chromosome . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nuclear export is mediated at least in part by XPO1/CRM1 (PubMed:12676962). Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B (PubMed:15311285). Proteolytic cleavage at the C-terminus by SPRTN promotes removal from chromatin (PubMed:31316063). .
