FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
c-Fgr
反应性
Human,Mouse
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
59kD
推荐稀释比
WB 1:500-1:2000;IHC 1:200-1:1000;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human c-Fgr expressed in E. Coli.
特异性
c-Fgr Monoclonal Antibody detects endogenous levels of c-Fgr protein.
基因名称
FGR
蛋白名称
Tyrosine-protein kinase Fgr
别名
FGR;SRC2;Tyrosine-protein kinase Fgr;Gardner-Rasheed feline sarcoma viral;v-fgr;oncogene homolog;Proto-oncogene c-Fgr;p55-Fgr;p58-Fgr;p58c-Fgr
Organism-1
Human
基因ID-1
2268
SwissProt-1
P09769
Organism-2
Mouse
基因ID-2
14191
SwissProt-2
P14234
背景
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane . Mitochondrion intermembrane space . Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. .
