FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
CD4
反应性
Human
应用
Flow Cyt,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
推荐稀释比
Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications;
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human CD4 expressed in E. Coli.
特异性
CD4 Monoclonal Antibody detects endogenous levels of CD4 protein.
基因名称
CD4
蛋白名称
T-cell surface glycoprotein CD4
别名
CD4;T-cell surface glycoprotein CD4;T-cell surface antigen T4/Leu-3;CD antigen CD4
Organism-1
Human
基因ID-1
920
SwissProt-1
P01730
Organism-2
Mouse
SwissProt-2
P06332
背景
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010],
细胞定位
Cell membrane ; Single-pass type I membrane protein . Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
