FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Brk
反应性
Human
应用
WB,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
52kD
推荐稀释比
WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human Brk expressed in E. Coli.
特异性
Brk Monoclonal Antibody detects endogenous levels of Brk protein.
基因名称
PTK6
蛋白名称
Protein-tyrosine kinase 6
别名
PTK6;BRK;Protein-tyrosine kinase 6;Breast tumor kinase;Tyrosine-protein kinase BRK
Organism-1
Human
基因ID-1
5753
SwissProt-1
Q13882
Organism-2
Mouse
SwissProt-2
Q64434
背景
protein tyrosine kinase 6(PTK6) Homo sapiens The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012],
细胞定位
Cytoplasm. Nucleus. Cell projection, ruffle. Membrane . Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.
