FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
BMPR-II
反应性
Human,Mouse,Rat,Monkey
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
115kD
推荐稀释比
WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human BMPR-II expressed in E. Coli.
特异性
BMPR-II Monoclonal Antibody detects endogenous levels of BMPR-II protein.
基因名称
BMPR2
蛋白名称
Bone morphogenetic protein receptor type-2
别名
BMPR2;PPH1;Bone morphogenetic protein receptor type-2;BMP type-2 receptor;BMPR-2;Bone morphogenetic protein receptor type II;BMP type II receptor;BMPR-II
Organism-1
Human
基因ID-1
659
SwissProt-1
Q13873
Organism-2
Mouse
基因ID-2
12168
SwissProt-2
O35607
背景
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disea
细胞定位
Cell membrane ; Single-pass type I membrane protein.
