FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
MCM2
反应性
Human,Mouse,Rat,Monkey
应用
WB,IHC,IF,Flow Cyt,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
102kD
推荐稀释比
WB 1:500-1:2000;IHC 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human BM28 expressed in E. Coli.
特异性
BM28 Monoclonal Antibody detects endogenous levels of BM28 protein.
基因名称
MCM2
蛋白名称
DNA replication licensing factor MCM2
别名
MCM2;BM28;CCNL1;CDCL1;KIAA0030;DNA replication licensing factor MCM2;Minichromosome maintenance protein 2 homolog;Nuclear protein BM28
Organism-1
Human
基因ID-1
4171
SwissProt-1
P49736
Organism-2
Mouse
基因ID-2
17216
SwissProt-2
P97310
背景
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012],
细胞定位
Nucleus . Chromosome . Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. .
