FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
ANP32A
反应性
Human
应用
WB,IHC,IF,ELISA
宿主物种-Host Species
Mouse
修饰-Modification
Unmodified
MW(Calculated)
29kD
推荐稀释比
WB 1:500-1:2000;IHC 1:200-1:1000;ELISA 1:10000;IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
Affinity purification
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
克隆性
Monoclonal
免疫原
Purified recombinant fragment of human ANP32A expressed in E. Coli.
特异性
ANP32A Monoclonal Antibody detects endogenous levels of ANP32A protein.
基因名称
ANP32A
蛋白名称
Acidic leucine-rich nuclear phosphoprotein 32 family member A
别名
ANP32A;C15orf1;LANP;MAPM;PHAP1;Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic nuclear phosphoprotein pp32;Leucine-rich acidic nuclear protein;LANP;Mapmodulin;Potent heat-stable protein phosphatase 2A inhibito
Organism-1
Human
基因ID-1
8125
SwissProt-1
P39687
Organism-2
Mouse
SwissProt-2
O35381
背景
function:Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.,PTM:Phosphorylated on serine residues.,PTM:The N-terminus is blocked.,similarity:Belongs to the ANP32 family.,similarity:Contains 4 LRR (leucine-rich) repeats.,subcellular location:Shuttles between nucleus and cytoplasm.,subunit:Component of the SET complex, which also contains SET, APEX1, HMGB2 and NME1. Directly interacts with SET. Interacts with ATXN1/SCA1. Interacts with MAP1B (By similarity). Interacts with ELAVL1. Part of the INHAT (inhibitor of histone acetyltransferases) complex. Interacts with E4F1.,tissue specificity:Expressed in all tissues tested. Highly expressed in kidney and skeletal muscle, moderate levels of expression in brain, placenta and pancreas, and weakly expressed in lung. Found in all regions of the brain examined (amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus), with highest levels in amygdala.,
细胞定位
Nucleus . Cytoplasm . Endoplasmic reticulum. Translocates to the cytoplasm during the process of neuritogenesis (By similarity). Shuttles between nucleus and cytoplasm. .
