FGF-2 Polyclonal Antibody
¥680.00
DNA pol β (Acetyl Lys72) rabbit pAb
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2600414
- 产品信息
商品描述
靶点-Target
DNA pol β
反应性
Human,Mouse,Rat
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Acetyl
MW(Observed)
38kD
推荐稀释比
WB 1:1000-2000;ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human DNA pol β (Acetyl Lys72)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat DNA pol β (Acetyl Lys72)
基因名称
POLB
蛋白名称
DNA pol β (Acetyl Lys72)
别名
DNA polymerase beta;EC 4.2.99.-;
Organism-1
Human
基因ID-1
5423
SwissProt-1
P06746
Organism-2
Mouse
基因ID-2
18970
SwissProt-2
Q8K409
Organism-3
Rat
基因ID-3
29240
SwissProt-3
P06766
背景
catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Binds 2 magnesium ions per subunit.,domain:Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.,function:Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.,PTM:Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.,similarity:Belongs to the DNA polymerase type-X family.,subunit:Monomer.,
细胞定位
Nucleus. Cytoplasm. Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.
