FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Karyopherin α2
反应性
Human,Mouse,Rat
应用
WB,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Acetyl
MW(Observed)
60kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human Karyopherin α2 (Acetyl Lys22)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat Karyopherin α2 (Acetyl Lys22)
基因名称
KPNA2 RCH1 SRP1
蛋白名称
Karyopherin α2 (Acetyl Lys22)
别名
Importin subunit alpha-2;Karyopherin subunit alpha-2;RAG cohort protein 1;SRP1-alpha;
Organism-1
Human
基因ID-1
3838
SwissProt-1
P52292
Organism-2
Mouse
基因ID-2
16647
SwissProt-2
P52293
背景
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J re
细胞定位
Cytoplasm . Nucleus .; Endoplasmic reticulum membrane. Golgi apparatus membrane . (Microbial infection) Retained in ER/Golgi membranes upon interaction with SARS-COV virus ORF6 protein. .
