FGF-2 Polyclonal Antibody
¥680.00
- 产品信息
商品描述
靶点-Target
Plasma Kallikrein LC
反应性
Human,Rat,Mouse,
应用
WB,ELISA,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
28kD,70kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human Plasma Kallikrein LC (Cleaved-I391)
特异性
This antibody detects endogenous levels of Human Cleaved-Plasma Kallikrein LC (I391, protein was cleaved amino acid sequence between 390-391 )
基因名称
KLKB1 KLK3
蛋白名称
Plasma Kallikrein LC (Cleaved-I391)
别名
Plasma kallikrein;Fletcher factor;Kininogenin;Plasma prekallikrein;[Cleaved into: Plasma kallikrein heavy chain;Plasma kallikrein light chain]
Organism-1
Human
基因ID-1
3818
SwissProt-1
P03952
Organism-2
Mouse
基因ID-2
16621
SwissProt-2
P26262
Organism-3
Rat
SwissProt-3
P14272
背景
catalytic activity:Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.,disease:Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect.,function:The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 4 apple domains.,subunit:The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.,
细胞定位
Secreted.
