FGF-2 Polyclonal Antibody
¥680.00
MMP8 (Cleaved-Leu101) rabbit pAb
活动价：
¥680.00
市场价：¥880.00
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产品规格：
- 50μL
- 100μL
货号：
FAB2600184
- 产品信息
商品描述
靶点-Target
MMP-8
反应性
Human,Mouse,Rat
应用
WB,IHC
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
40kD,53kD
推荐稀释比
WB 1:500-2000;IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human MMP8 (Cleaved-Leu101)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat MMP8 (Cleaved-Leu101, protein was cleaved amino acid sequence between 100-101 )
基因名称
MMP8 CLG1
蛋白名称
MMP8 (Cleaved-Leu101)
别名
Neutrophil collagenase;Matrix metalloproteinase-8;MMP-8;PMNL collagenase;PMNL-CL;
Organism-1
Human
基因ID-1
4317
SwissProt-1
P22894
Organism-2
Mouse
基因ID-2
17394
SwissProt-2
O70138
Organism-3
Rat
基因ID-3
63849
SwissProt-3
O88766
背景
catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 3 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Cannot be activated without removal of the activation peptide.,function:Can degrade fibrillar type I, II, and III collagens.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,subcellular location:Stored in intracellular granules.,tissue specificity:Neutrophils.,
细胞定位
Cytoplasmic granule. Secreted, extracellular space, extracellular matrix . Stored in intracellular granules.
