FGF-2 Polyclonal Antibody
¥680.00
MASP1 (light chain, Cleaved-Ile449) rabbit pAb
活动价：
¥680.00
市场价：¥880.00
一键复制产品信息
产品规格：
- 50μL
- 100μL
货号：
FAB2600138
- 产品信息
商品描述
靶点-Target
MASP1
反应性
Human,Rat,Mouse,
应用
WB,ELISA
宿主物种-Host Species
Rabbit
同种型-Isotype
IgG
修饰-Modification
Unmodified
MW(Observed)
20kD,77kD
推荐稀释比
WB 1:1000-2000;ELISA 1:5000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
克隆性
Polyclonal
免疫原
Synthesized peptide derived from human MASP1 (light chain, Cleaved-Ile449)
特异性
This antibody detects endogenous levels of Human MASP1 (light chain, Cleaved-Ile449, protein was cleaved amino acid sequence between 448-449 )
基因名称
MASP1 CRARF CRARF1 PRSS5
蛋白名称
MASP1 (light chain, Cleaved-Ile449)
别名
Mannan-binding lectin serine protease 1;Complement factor MASP-3;Complement-activating component of Ra-reactive factor;Mannose-binding lectin-associated serine protease 1;MASP-1;Mannose-binding protein-associated serine protease;Ra-reactive factor serine protease p100;RaRF;Serine protease 5;[Cleaved into: Mannan-binding lectin serine protease 1 heavy chain;Mannan-binding lectin serine protease 1 light chain]
Organism-1
Human
基因ID-1
5648
SwissProt-1
P48740
Organism-2
Mouse
基因ID-2
17174
SwissProt-2
P98064
Organism-3
Rat
基因ID-3
64023
SwissProt-3
Q8CHN8
背景
enzyme regulation:Inhibited by SERPING1 and A2M.,function:Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.,PTM:Autoproteolytic processing of the proenzyme produces the active enzyme composed on the heavy and the light chain held together by a disulfide bond. Isoform 1 but not isoform 2 is activated through autoproteolytic processing.,PTM:N-glycosylated. Some N-linked glycan are of the complex-type.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 CUB domains.,similarity:Contains 2 Sushi (CCP/SCR) domains.,subunit:Homodimer. Interacts with the oligomeric lectins MBL2, FCN2 and FCN3; triggers the lectin pathway of complement through activation of C3. Interacts with SERPING1.,tissue specificity:Protein of the plasma which is primarily expressed by liver.,
细胞定位
Secreted .
